1038277--3/31/2010--INTERNATIONAL_ISOTOPES

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We do not have an operating history with respect to our strategy to combine de-conversion services and FEP produced fluoride gas products and this business may not succeed. We do not have contracts to provide de-conversion services to enrichment firms or off take agreements for the fluoride gases we will produce. Large scale commercial fluoride gas production utilizing FEP has not been performed. We will need to raise additional funds to complete the construction of our hybrid de-conversion FEP facility. The licensing and environmental permitting process with respect to the construction of our hybrid de-conversion and FEP facility is ongoing and we cannot predict the amount of time required to obtain approval from the Nuclear Regulatory Commission for construction and operation of these facilities, or that approval will be granted at all We have incurred and may continue to incur losses We will need additional financing to continue operations. Operational hazards could result in the spread of contamination within our facility and require additional funding to correct We may incur material losses and costs as a result of product liability claims that may be brought against us dependent upon key personnel, particularly our President and Chief Executive Officer. We are dependent on various third parties in connection with our business operations We are dependent on a limited number of customers in connection with our business operations We are subject to competition from other companies . General economic conditions in markets in which we do business can impact the demand for our goods and services. Decreased demand for our products and services can have a negative impact on our financial performance and cash flow. Volatility in raw material and energy costs, interruption in ordinary sources of supply and an inability to recover unanticipated increases in energy and raw material costs from customers could result in lost sales or significantly increase the cost of doing business. We are subject to extensive government regulation in jurisdictions around the globe in which we do business. Regulations address, among other things, environmental compliance, import/export restrictions, healthcare services, taxes and financial reporting, and can significantly increase the cost of doing business, which in turn can negatively impact our operations, financial results and cash flow. We expect to be handling large quantities of depleted uranium and fluoride gasses, which are radioactive and hazardous materials respectively, and are subject to intense regulation . Our earnings, cash flow, and financial position are exposed to financial market risks worldwide, including interest rates. Catastrophic events such as natural disasters, pandemics, war and acts of terrorism, could disrupt our business or the business of our suppliers or customers, and any such disruptions could have a negative impact on our operations, financial results and cash flow. Our future growth is largely dependent upon our ability to develop new technologies that achieve market acceptance with acceptable margins. Protecting our intellectual property is critical to our innovation efforts Trading in our common stock is limited and the price of our common stock may be subject to substantial volatility. We are contractually obligated to issue shares in the future, which will dilute your interest in us.

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1038277--3/31/2010--INTERNATIONAL_ISOTOPES_INC