1095330--2/27/2007--SYMYX_TECHNOLOGIES

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Most of our revenue is generated from a small number of key customers and the loss of or reduction in business from a key customer could substantially reduce our revenues and be perceived as a loss of momentum in our business Failure to integrate our products that we acquired through acquisitions and failure to achieve customer acceptance of the ELN technology and precision powder-dispensing equipment would harm our revenue and operating results Business activities such as the development of a new line of business or the acquisition of a company or technology could disrupt our business, affect our operating results and distract our management team We may not be able to maintain and grow a profitable business Failure to successfully commercialize our discoveries would reduce our revenues and profitability and harm our business We are dependent on the research and development activities of companies in the chemical, energy, life science, consumer product, and other industries, and declines or reductions in research and development activities in these industries could harm our business We cannot predict the pace, quality, or number of discoveries we may generate, and any inability of ours to generate a significant number of discoveries would reduce our revenues and harm our business Difficulties we may encounter managing our growth may divert resources and limit our ability to successfully expand our operations We conduct research programs for our own account and for a number of collaborative partners, and any conflicts between these programs would harm our business We have a limited number of contracts for the sale of Symyx Tools and for the licensing of intellectual property, software, technologies, and materials to date, and we cannot assure you that we will be able to build a sustainable business related to either the sale of additional systems or the licensing of intellectual property, software, technologies, and materials The loss of key personnel or the inability to attract and retain additional personnel could have a material adverse effect on our results of operations Competition could increase, and competitive developments could render our technologies obsolete or noncompetitive, which would reduce our revenues and harm our business Our inability to adequately protect our proprietary technologies could harm our competitive position and have a material adverse effect on our business Failure to adequately enforce our intellectual property rights could harm our competitive position and have a material adverse effect on our business Our business may be harmed if we are found to infringe proprietary rights of others We have engaged in business relationships with early stage companies whose ability to perform all their obligations is less certain than our traditional large chemical, energy, life science, and consumer product customers We expect that our quarterly results of operations will fluctuate, and this fluctuation could cause our stock price to decline, causing investor losses Our stock price has been and may continue to be volatile We depend on a limited number of suppliers and will be delayed in our manufacture or unable to manufacture our Symyx Tools if shipments from these suppliers are delayed or interrupted Key parts of our Symyx Tools are currently available only from a single source or a limited number of sources. In addition, components of our capital equipment are available from one or only a few suppliers. In the event that supplies from these vendors are delayed or interrupted for any reason, we may not be able to get equipment or components for Symyx Tools or our own research efforts in a timely fashion or in sufficient quantities or under acceptable terms. Our investments could lose market value and consequently harm our ability to fund continuing operations Changes in accounting standards regarding stock option plans could limit the desirability of granting stock options, which could harm our ability to attract and retain employees, reduce our profitability and may affect our stock price Failure to maintain effective internal controls in accordance with Section 404 of the Sarbanes-Oxley Act could have a material adverse effect on our business and stock price If our products contain defects, it could harm our revenues and expose us to litigation We are exposed to general global economic and market conditions We are exposed to risks associated with export sales and international operations that may limit our ability to generate revenue from our products and intellectual property Any inability of ours to keep pace with technological advances and evolving industry standards would harm our business We use hazardous materials in our business, and any claims relating to improper handling, storage, or disposal of these materials could subject us to significant liabilities Compliance with current and future environmental regulations may be costly which could impact our future earnings. Our facilities are located near known earthquake fault zones, and the occurrence of an earthquake or other disaster could cause damage to our facilities and equipment and harm our business Some of our existing stockholders can exert control over us, and may not make decisions that are in the best interests of all stockholders Provisions of our charter documents may have anti-takeover effects that could prevent a change in our control, even if this would be beneficial to stockholders

Full 10-K form ▸

1095330--2/27/2007--SYMYX_TECHNOLOGIES_INC