706539--3/16/2006--CHIRON

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F. Hoffmann-La Roche A.G. and Roche Diagnostics GmbH HCV Investigation of Employees of Italian Subsidiary Laboratory Corporation of America Holdings Novartis AG Proposed Acquisition Shareholder Suits Senate Finance Committee Information Request EXECUTIVE OFFICERS OF THE REGISTRANT Influenza Virus Vaccines Recent Events Critical Accounting Policies and the Use of Estimates Revenues from joint business arrangement Royalty and license fee revenues Selling, general and administrative expenses Royalty and license fee revenues Selling, general and administrative expenses Impairment loss on acquired intangible assets Royalty and license fee revenues Selling, general and administrative expenses Royalty and license fee revenues Selling, general and administrative expenses Purchased in-process research and development Interest and other income, net Sources and Uses of Cash Factors That May Affect Future Results (a) Evaluation of disclosure controls and procedures (b) Management s annual report on internal control over financial reporting (c) Report of the independent registered public accounting firm on internal control over financial reporting (d) Changes in internal controls

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706539--3/16/2006--CHIRON_CORP